Job Details

Senior Scientist, Oligonucleotides Design and Chemistry

  2026-04-02     R&D Partners     South San Francisco,CA  
Description:

We are seeking a talented and dynamic individual with extensive oligonucleotide experience to join our team as a Scientist/Senior Scientist. This role offers a significant opportunity to impact our science and pipeline by leading the design and synthesis of novel oligonucleotides for drug discovery programs. The successful candidate will be a technical leader, guiding a dedicated team and taking on responsibilities across the portfolio.

This is a 12-month contract based in South San Francisco, CA.

Responsibilities

  • Demonstrated ability to both lead and support multiple parallel projects and thrive in highly collaborative team environments.
  • Lead the design, synthesis, and characterization of novel oligonucleotides for various portfolio programs.
  • Provide mentorship to junior scientists in the synthesis and characterization of new oligonucleotide sequences.
  • Serve as a leader or active participant in cross-disciplinary discussions to ensure effective execution of portfolio programs.
  • Collaborate with biology and biochemistry teams to design and execute novel assays, facilitating rapid go/no-go decisions.
  • Take a leading role in managing all aspects of laboratory instrumentation and maintaining smooth operations.
  • Maintain a strong collaborative mindset and demonstrate excellent written and verbal communication skills.

Qualifications

  • Must have attained a Masters Degree or higher in required majors Chemistry, biochemistry, chemical biology, or related fields.
  • Extensive hands-on experience in the synthesis, purification, and analytics of siRNA and/or ASO therapeutics.
  • In-depth knowledge of oligonucleotide/peptide therapeutics, including chemical structure search tools, synthesis techniques, purification instrumentation, and analysis methods for chemically modified oligonucleotides.

Salary

  • $130,832-$173,324

Why Choose R&D Partners?

As an employee, you have access to a comprehensive benefits package including:

  • Medical insurance – PPO, HMO & HSA
  • Dental & Vision insurance
  • 401k plan
  • Employee Assistance Program
  • Long-term disability
  • Weekly payroll
  • Expense reimbursement
  • Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.


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