Job Details

Job Title: Scientist

Location: South San Francisco, CA 94080

Duration: 12 months

Ideal Candidate:

• PhD is a MUST (The ideal candidate is a recent PhD graduate in Biochemistry, Chemical Biology, Molecular Biology, or a related field, with strong quantitative and analytical skills)

• This role is best suited for early-career scientists (0–2 years of postdoctoral or industry experience)

Preferred Qualifications:

• Strong scientific foundation in understanding and implementing various bioassays and readouts, including TR-FRET, BRET, Alpha, MSD, HCS, luminescence, and fluorescence.

• Expertise in the development and implementation of target engagement (TE), activity, functional, and phenotypic, and protein-protein interaction (PPI) assays to assess therapeutic agents, including thermal shift assay (TSA), probe displacement, second messenger, ion flux, reporter, protein stability, PPI (NanoBiT, NanoBRET, etc.), immunoassays, gene activation, and cellular imaging.

• Extensive experience in the functional and phenotypic characterization of engineered cells with analytical techniques, including DNA sequencing, RT-qPCR, and Western Blots

• Experience in a variety of bioassays on more physiologically relevant cellular models such as iPSCs, 3D-culture, co-culture, and primary cells.

• Competence in setting up and operating multimode plate readers (e.g., PHERAstar, CLARIOstar, FLIPR, EnVision) and automated liquid handlers (e.g., Echo, Dragonfly, Multidrop Combi, Bravo, BioTek Plate Washer, BlueWasher) for the development of 384- and/or 1536-well microtiter plate assays.

• Familiarity with software and statistical platforms necessary for analyzing large data sets, including Screener and Spotfire