Job Details

Vice President, Clinical Operations

TCG Labs-Soleil, established in partnership with The Column Group, a premier science‑focused venture capital firm, is pioneering a novel ‘venture capital‑biotech' model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. The model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top‑tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single‑asset portfolio companies, strategically poised for transacting after clinical PoC.

The VP, Clinical Operations is accountable for timely, end‑to‑end quality evidence generation in support of Soleil's clinical corporate goals through management and oversight of Clinical Operations. The VP will report to the Chief Medical Officer and provide subject‑matter expertise and guidance to cross‑functional teams in a fast‑paced, high‑growth environment to ensure that clinical trials are conducted on time and budget, and in accordance with applicable GCP/ICH guidelines and other regulatory requirements. This is an on‑site/hybrid role based in South San Francisco.

Base pay range

$300,000.00/yr - $360,000.00/yr

Primary Responsibilities

• Accountable for maintaining oversight of clinical programs to ensure timely and high‑quality study execution, data generation and analysis to support regulatory filings.
• Accountable for delivering on clinical operations scenario planning, high‑level forecasting of timelines, assessment of program level feasibility.
• Accountable for ensuring resource availability to maintain inspection‑readiness across clinical programs.
• Accountable for preparing and presenting trial parameters and clinical information to executive leadership, vendors, and other key stakeholders.
• Responsible for identification, prioritization, and definition of new processes and systems to support organizational growth.
• Responsible for developing hiring and retention strategies to ensure appropriate resourcing across the Clinical Operations.
• Responsible for providing input, as needed, to clinical and regulatory documents.

Requirements

• Bachelor's degree required, higher degrees in life sciences preferred
• At least 15 years of experience working with clinical research organization to manage global clinical trials. Rare disease experience is a plus.
• At least 10 years experience managing direct reports, evidencing strong leadership, team‑building, and hands‑on management.
• Demonstrated ability to build high‑functioning teams that can adapt to changing priorities.
• Demonstrated knowledge of the drug development process in the bio/pharmaceutical industry with an understanding of relevant regulatory requirements.
• Comprehensive understanding of ICH and GCP guidelines, as well as applicable regulations and practices.
• Excellent organizational skills and attention to detail.
• Effective communication and interpersonal skills.
• Able to set priorities and juggle multiple demands.
• Able to think critically, diagnose root causes and be a proactive problem‑solver.
• Able to work independently while exercising initiative, flexibility and sound judgment.
• Comfortable working with different levels of the company including senior level management.

Compensation

• The annual base salary for this role is $300-360K. Individual pay may vary based on additional factors, including, and without limitation, job‑related skills, experience, work location and relevant education or training. The total compensation package includes benefits, equity, and annual target bonus for full‑time positions.

Seniority level

Executive

Employment type

Full‑time

Job function

Research, Science, and Management

Industries

Biotechnology Research and Pharmaceutical Manufacturing