Job Details

Caribou Biosciences is a leading clinical‑stage CRISPR genome‑editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. Our next‑generation genome‑editing technology enables precision cell therapies that are armored to improve activity against diseases. We believe the future of cell therapy is off‑the‑shelf and are advancing a pipeline of allogeneic cell therapies from our CAR‑T platform as readily available treatments for patients with hematologic malignancies and autoimmune diseases.

Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when members are personally engaged, ideas are taken seriously, and contributions are recognized. Members of the herd work from our headquarters in Berkeley, California, or remotely.

Position Summary

We are seeking a highly motivated and experienced Senior Manager of Clinical Biomarkers to join our Translational Research team. The candidate will be accountable for implementing the clinical biomarker strategy of gene‑edited allogeneic cell therapy clinical programs at Caribou, with a particular emphasis on Multiple Myeloma programs. The candidate will generate biomarker insights crucial to ensuring precise patient selection, therapy response monitoring, and safety assessments.

Key Responsibilities

• Lead the development and execution of clinical biomarker plans aligned with Caribou's clinical development strategy.
• Prepare, update, and finalize documentation for regulatory submissions such as biomarker‑related sections in clinical protocols, investigator brochures, clinical study reports, and other related biomarker documents.
• Lead biomarker‑related activities across all phases of clinical trials, ensuring alignment with study objectives, timelines, and budget.
• Organize, analyze results, interpret emerging clinical biomarker data, and communicate effectively at research and cross‑functional meetings and senior management.
• Participate in program development teams and lead pertinent translational research working groups.
• Oversee the discovery, validation, and qualification of biomarkers and methods to inform mechanism of action, response/resistance, safety, disease monitoring, and treatment response evaluation of Caribou's allogeneic cell therapy drug products.
• Liaise and support cross‑functional translational research teams including computational biology, clinical teams, and lab scientists for biomarker analysis, back‑translation, and exploration of translational strategies such as indication or patient selection.

Qualifications

• Ph.D. in Oncology, Immunology, or related field with 5+ years of industry experience and 3+ years in oncology/biomarkers/translational or correlative research.
• Ability to develop and execute biomarker plans aligned with overall clinical development goals and corporate objectives.
• Demonstrated experience in designing and leading clinical biomarker components of phase I–III clinical trials in the biopharmaceutical industry.
• Familiarity with interpreting and integrating biomarker data to drive decision‑making in clinical trials.
• Familiarity with Multiple Myeloma regulations and clinical biomarkers including PK/PD/MRD assays.
• Understanding of regulatory requirements and guidelines related to biomarker development and utilization in cell therapy clinical trials (e.g., FDA, EMA, ICH guidelines).
• Experience in designing and execution of translational research, in‑vitro and in‑vivo pharmacology, and mechanism of action studies is preferred.
• Experience managing external vendors and biomarker operations.
• Excellent written and verbal communication skills, including the ability to present complex biomarker data effectively to diverse audiences.
• Familiarity with cell therapy and Multiple Myeloma landscapes, including competitive products, emerging trends, and current challenges.
• Able to adapt to a dynamic and rapidly changing company environment, and to adjust workload according to shifting priorities.

Compensation and Benefits

• Competitive salary, bonus, and equity for all employees.
• Salary Range: $170000 – $200,000. Actual pay will vary based on location, experience, and performance.
• Generous paid vacation time and company-observed holidays.
• Excellent medical, dental, and vision insurance.
• 401(k) retirement savings plan with matching employer contributions.
• Employee stock purchase plan (ESPP).

Caribou is an equal‑opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (including pregnancy, childbirth, and breastfeeding), genetic information, or taking or requesting statutorily protected leave, hair texture or type, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.

Legal authorization to work in the United States is required. All persons hired will be required to verify identity and eligibility to work in the United States and complete the required employment eligibility verification form upon hire.