Job Details

Job Post Title
Scientist II – Single cell and spatial omics

Estimated Base Salary
Market rate, Offers Equity

Employment Type
Full-time

Job Functions
Technology innovation, Assay development

Seniority Level
Associate

The Role

We're looking for a molecular biologist with sharp experimental intuition to drive development of our core omics chemistry. You'll take ownership of assay design, reagent formulation, and protocol optimization. The ideal candidate brings systems-level thinking to assay design, understanding how workflow variables influence metrics such as UMI capture rate, transcript integrity, and gene dropout frequency. Experience with single-cell or spatial omics workflows is strongly preferred.

What you will be working on

• Contribute to the creative vision for our measurement platform.
• Design and test novel scaffolds for spatially resolved single-cell measurement.
• Develop and optimize workflows compatible with tissue fixation protocols.
• Create novel chemical linkers for spatial barcoding and molecular capture.
• Collaborate with data scientists to align assay design with ML pipelines.
• Develop novel integrations of enzymatic reactions to simplify workflows.
• Standardize sample preparation and dissociation for clinical applications.
• Stay at the cutting edge of molecular and biochemical advancements.

What you should know or have

• BS, MS, or PhD in Genetics, Molecular Biology, Biochemistry, or a related field.
• Minimum of 2 years (PhD) of relevant hands-on experience.
• Deep expertise in molecular technologies and single-cell/spatial sequencing.
• Creative problem-solving and ability to work in multidisciplinary teams.

Sampling Human is introducing single-cell and spatial sequencing solutions for clinical applications. We're revealing a new layer of biological information that enables earlier, more precise insights and drives longer, healthier lives. Our products combine genomic measurements with AI-generated biology in end-to-end data pipelines that redefine what's measurable at scale.

We're a small, well-funded, mission-driven team of molecular and cell biologists, software and automation engineers, mathematicians, computer scientists, and business professionals, all building at the convergence of computation and biology. At Sampling Human, you'll do foundational work, chase ambitious ideas, and deliver products that directly impact health. You'll also get access to a cutting-edge tech stack and proprietary datasets that uncover the most interesting cells in the human body at scale.

If you want to build human informatics from the ground up, you are in the right place.