Job Details

Overview

Renasant Bio is seeking a Senior Scientist with deep expertise in cell-based assay development, 3D cellular systems, high-content imaging, and phenotypic assays to lead and expand our discovery platform for kidney diseases. You will manage and mentor a small team, own assay strategy from concept to deployment, and partner cross-functionally to execute disease relevant assays that drive target validation and lead optimization. The ideal candidate blends hands-on technical strength with rigorous data analytics and a builder's mindset.

Responsibilities

• Lead, mentor, and develop junior scientists; set goals, review data, and ensure on-time, high-quality execution.
• Assay development & miniaturization: Design, optimize, and execute 2D and 3D cell-based imaging assays for phenotypic assay validation and MoA exploration.
• Establish rigorous QC metrics, TPP-aligned acceptance criteria, and SOPs enabling internal use and CRO tech transfer.
• Phenotypic screening & analytics: Build high-content screening workflows for target validation; implement pipelines for image processing, feature extraction, normalization, and data visualization/dashboards; drive data-driven decision-making.
• Integrate automated liquid handling and scheduling (e.g., Tecan) to boost throughput and reproducibility; monitor assay health over time.
• Cross-functional impact: Collaborate with medicinal chemistry, and translational teams to align assays to program strategy and timelines.
• Manage external collaborations/CROs and contribute to study design, tech transfer, and data reviews.
• Scientific leadership: Stay current on advances in kidney disease biology, 3D models, imaging, and screening technologies; propose platform innovations.
• Communicate results and recommendations to internal/external stakeholders with clarity and influence; effectively document experimental analyses.

Qualifications

• Ph.D. in Cell Biology, Physiology, Pharmacology, Bioengineering, or related field with 5+ years industry experience in small-molecule drug discovery.
• Proven track record developing quantitative high-content imaging assays and phenotypic screens in mammalian systems.
• Hands-on expertise with 3D cultures and assay characterization for translational relevance.
• Experience with assay automation and miniaturization; strong understanding of plate-based statistics (Z', %CV, S/B, controls).
• Proficiency with imaging analysis platforms (ImageJ/Fiji, MetaXpress, Zen, CellProfiler); working ability in Python/R/SQL for image/feature analytics preferred.
• Demonstrated ability to lead projects and people in a fast-paced setting; excellent written and verbal communication skills.
• Passion for advancing therapies for kidney disease and solving complex biological problems with rigor and creativity.