Job Details

Scientist Disease Profiling - South San Francisco CA

Scientist Disease Profiling

What you will do:

Let's do this. Let's change the world. In this vital role you will join the Target Discovery and Biology team in South San Francisco. This role is at the frontier of disease biology, using innovative sequencing technologies to identify novel therapeutic targets across Amgen's key therapeutic areas including oncology, inflammation, and cardiovascular and metabolic diseases. You will bring expertise in advanced sequencing technologies and disease profiling to support target discovery, validation, and mechanism-of-action studies. You will play a key role in driving innovation, developing technologies, and integrating multi-omic approaches to advance Amgen's discovery pipeline.

Responsibilities:

• Design, implement, and deliver omics data using advanced sequencing platforms such as long-read sequencing and leverage multi-omic data to help characterize disease biology as well as cell and animal models.
• Identify and implement developing and impactful omics technologies to advance drug discovery.
• Operate and maintain in-house NGS sequencing instruments.
• Apply computational, statistical, and machine learning methods to analyze internally-generated and publicly-available omics datasets in collaboration with the bioinformatics team.
• Collaborate across multidisciplinary teams in various Amgen therapeutic areas to accelerate target discovery.
• Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums.
• Maintain organized project records, electronic lab notebooks and code/data repositories.

What we expect of you:

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications:

• Basic Qualifications: Doctorate degree or Master's degree and 2 years of relevant scientific experience or Bachelor's degree and 4 years of relevant scientific experience
• Preferred Qualifications:
• Hands-on expertise in data generation using advanced sequencing technologies including long-read sequencing platforms (e.g. PacBio, Oxford Nanopore).
• Hands-on experience with single-cell RNA-seq technologies (library prep and analysis).
• Proficiency in programming (e.g. in R/Python), Unix/Linux environments, and cloud computing environments for the analysis of long-read sequencing and large omics datasets including isoform sequencing analysis.
• Experience with polysome-seq or ribo-seq would be plus.
• Ability to quickly adopt novel and developing methods.
• Demonstrated track record of independent critical thinking, complex problem solving, and innovative research (e.g. significant contributions to pipeline programs and/or publications in top tier journals).
• Strong written, verbal and organizational skills and the ability to work in a fast-paced multi-disciplinary team.

What you can expect from us:

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.