Job Details

Nura Bio, Inc. (Nura Bio) is a clinical-stage biopharmaceutical company developing neuroprotective therapies for the treatment of a broad range of neurological diseases. Nura Bio's research and early development small molecule pipeline is focused on developing therapies that halt axon degeneration and/or modulate microglial responses to degeneration and injury, with the goal of conferring neuroprotection, across diseases of the central, peripheral, and ocular nervous system.

The Head of Clinical Pharmacology will be responsible for establishing and leading the pharmacology function, providing scientific and strategic leadership to integrate model-informed drug development (MIDD) into clinical and regulatory decision-making. This role will partner closely with Preclinical, Translational, Regulatory, and Clinical teams to develop quantitative strategies for dose selection, trial design, and understanding of exposure-response relationships.

Nura Bio offers a comprehensive generous medical and dental insurance, vision, life and disability insurance, health savings account, flexible savings, and dependent care, 401(k) plan, and highly attractive stock options.

Nura Bio is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

To learn more about our mission and our science, visit us at www.nurabio.com. If you have the experience we are seeking and would like the opportunity to contribute to our mission, we would like to hear from you!

Please send your CV with a cover letter delineating why you are interested to ...@nurabio.com

What You Will Do:

• Be responsible for designing, executing, and interpreting the pharmacokinetic (PK), pharmacodynamic (PD), and exposure-response aspects of our development programs.
• Provide a critical leadership role in translational medicine, ensuring seamless integration of nonclinical and clinical data to inform dose selection, study design, and regulatory interactions
• Lead the design and execution of pharmacology strategies across all stages of development, with an emphasis on early-phase programs.
• Oversee population PK, PK/PD, exposure-response, and PBPK modeling to support internal decision-making and regulatory submissions.
• Serve as a key subject matter expert for pharmacometric components of clinical protocols, regulatory filings (IND, CTA, briefing documents), and global health authority interactions.
• Manage external consultants and CROs.
• Define standards and best practices for model-informed development within the company.
• Drive integration of preclinical, translational, and clinical data to inform optimal dose and schedule selection.
• Act as a strategic thought partner across functions to influence program-level and portfolio-level development decisions.
• Stay current with regulatory guidance and scientific advances in modeling and simulation.

• Ph.D. or Pharm.D. in pharmacometrics, clinical pharmacology, pharmacokinetics, or a related field, with 10+ years of experience in the pharmaceutical or biotechnology industry.
• Demonstrated leadership in pharmacometric strategy and successful regulatory interactions (e.g., IND, EOP1/2, NDA/BLA support).
• Expert knowledge of population PK/PD modeling, simulation, and quantitative pharmacology principles.
• Hands-on experience with software tools such as NONMEM, Monolix, R, Phoenix NLME, and other modeling platforms.
• Proven ability to work in cross-functional teams and influence key development and regulatory decisions.
• Experience in building or leading pharmacometric functions in a biotech or pharma setting is strongly preferred.
• Excellent scientific communication, leadership, and organizational skills.
• Ability to operate effectively in a dynamic, entrepreneurial, and resource-limited environment.