Job Details

Integrated Resources, Inc., is led by a seasoned team with combined decades in the industry. We deliver strategic workforce solutions that help you manage your talent and business more efficiently and effectively. Since launching in 1996, IRI has attracted, assembled, and retained key employees who are experts in their fields. This has helped us expand into new sectors and steadily grow.

Job Description

Position: Scientist II

Location: San Francisco, CA, United States

We are seeking a highly motivated, results-oriented, self-starter who demonstrates personal accountability for outcomes, to join a new and dynamic team responsible for the development and characterization of clinical-scale manufacturing processes for Chimeric Antigen Receptor T-cell (CART) therapies. The successful candidate will contribute to the development, implementation, and characterization of state-of-the-art processing technologies to deliver scalable and robust manufacturing processes, supporting successful tech transfer for GMP manufacturing and release at a CMO. This role will also involve developing novel technologies to meet future CART manufacturing needs, working closely with the CART Research and Bioprocess R&D groups.

1. Contribute to the development, implementation, and successful execution of robust CART manufacturing processes.
2. Support clinical-scale non-GMP / GMP IND-enabling manufacturing operations, including tech transfer to CMO and GMP manufacturing of clinical material.
3. Engage in innovation programs to enhance CART manufacturing technologies and processes, such as alternative transfection strategies, media development, disposable/closed systems, and automation, aligned with regulatory expectations.
4. Collaborate effectively within Project Technical Teams and communicate with all stakeholders.
5. Demonstrate leadership and accountability, applying scientific expertise to ensure safe, high-quality lab practices.
6. Maintain high-quality documentation in electronic lab notebooks and technical reports; contribute to regulatory filings and responses.
7. Present data and strategies to scientists and management in internal meetings.
8. Develop processes for manufacturing cell or gene therapies.
9. Culture and characterize primary T cells, including T cell molecular biology and engineering.
10. Engage in molecular virology and recombinant virus production/engineering.
11. Familiarity with cGMPs and regulatory guidance documents is a plus.

Qualifications

1. B.S. with 3+ years or M.S. with 2+ years in cellular biology or related biological sciences, preferably with experience in cell-scale studies and analytical troubleshooting.
2. Experience in analytical methods for characterization and GMP release of cell-based or gene therapies, especially flow cytometry and immunophenotyping.
3. Applied skills in cell biology, particularly in primary T cell culture, expansion, and immunologic characterization.

This job posting is active and accepting applications.